We work on new therapeutic and nutricional approaches based on Short-Chain Fatty Acids (SCFAs). They are vital to the balance of the microbiota and the development and health of the intestinal epithelium. SCFAs are produced when dietary fiber is fermented by the anaerobic intestinal microbiota. Main SCFAs are: Butyrate, Acetate and Propionate.
Figure 1. Production of Butyric acid & its Role in the Intestine
Figure 2. What is a ‘Dysbiotic Vicious Circle’ and How to Break it
Figure 3. Interactions between the diet & the gut microbiota dictate the production of short-chain fatty acids. “Butyrate-producing bacteria” such as Clostridiaceae, Lachnospiraceae and Ruminococcaceae biotransform carbohydrates & fiber into butyrate. The ability of the microbiota to biotransform various dietary components into functional metabolites is likely incapacitated when the ecosystem is disrupted by antibiotic treatments or altered by dietary manipulation. (Cell Host & Microbe. August 2014)